Tirzepatide

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How Tirzepatide Helps with Weight Loss

• Dual Hormone Action (GLP-1 & GIP)

• GLP-1: Reduces appetite, slows digestion, and regulates blood sugar.

• GIP: Enhances the body's ability to burn fat and improve insulin sensitivity.

• Greater Weight Loss Potential: Clinical trials suggest it may lead to higher weight loss than semaglutide.

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​Effectiveness

• SURMOUNT Trials (Clinical Studies)

  • Patients lost an average of 15-22% of their body weight over 72 weeks.

  • Outperformed semaglutide, which led to ~15% weight loss.

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Dosage and Administration

• Typically starts at 2.5 mg once a week, gradually increasing to 15 mg weekly (for weight loss).

• Administered as a subcutaneous injection in the stomach, thigh, or upper arm.

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Side Effects

• Common: Nausea, vomiting, diarrhea, constipation, bloating.

• Serious: Pancreatitis, gallbladder issues, kidney concerns, and thyroid tumors (black box warning).

• Tolerability: Some patients report fewer side effects compared to semaglutide.

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Who Should Avoid Tirzepatide?

• Individuals with a history of medullary thyroid cancer (MTC) or MEN2.

• Those with severe gastrointestinal conditions.

• Pregnant or breastfeeding women.

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Cost and Availability

• Expensive: ~$1,000+ per month without insurance.

• Insurance: Some plans cover Mounjaro for diabetes; Zepbound for weight loss may require prior authorization.

• Savings Programs: Eli Lilly offers a savings card for eligible patients with insurance, as well as lower price for self-pay patients (cash pay).

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Semaglutide vs. Tirzepatide: Which Is Better for Weight Loss?

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Compounded:

This version is a mix (compounded) of trizepatide, glycine, and B12.

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Glycine is a non-essential amino acid that plays a role in various bodily functions, including protein synthesis, neurotransmitter regulation, and metabolism. While it’s not a direct weight-loss supplement, it may support weight management in several ways.

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Potential Benefits of Glycine for Weight Loss

1. Supports Muscle Growth & Retention – Glycine is involved in protein synthesis, which helps preserve lean muscle mass during weight loss. More muscle mass can lead to a higher resting metabolic rate.

2. Improves Sleep Quality – Glycine has been shown to enhance sleep quality by promoting relaxation and lowering body temperature. Better sleep is linked to improved metabolism, appetite control, and reduced cravings.

3. Regulates Blood Sugar & Insulin Sensitivity – Some research suggests glycine can improve insulin sensitivity and regulate blood sugar, reducing the likelihood of insulin spikes that lead to fat storage.

4. Reduces Inflammation & Oxidative Stress – Chronic inflammation is associated with obesity and metabolic issues. Glycine has anti-inflammatory and antioxidant properties that may aid metabolic health.

5. Supports Gut Health – Glycine plays a role in maintaining gut lining integrity, which is important for digestion and nutrient absorption, potentially aiding weight management.

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Vitamin B12 plays a crucial role in metabolism, energy production, and red blood cell formation. While it doesn’t directly cause weight loss, it can support metabolic processes that contribute to a healthy weight.

 

How B12 May Help with Weight Loss

1. Boosts Energy Levels – B12 helps convert food into energy by assisting in carbohydrate and fat metabolism. Higher energy levels may improve physical activity and calorie burning.

2. Supports Metabolism – A deficiency in B12 can slow down metabolism, potentially leading to weight gain or difficulty losing weight.

3. Improves Mood & Reduces Stress – Low B12 levels are linked to fatigue, depression, and stress, which can contribute to overeating or poor food choices.

4. Enhances Red Blood Cell Production – B12 is essential for oxygen transport in the blood, which supports endurance and exercise performance.

5. May Help with Fat Breakdown – Some studies suggest B12 plays a role in breaking down fatty acids for energy, though more research is needed.